Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients
Identifieur interne : 000969 ( Main/Exploration ); précédent : 000968; suivant : 000970Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients
Auteurs : Marie-Quitterie Picat [France] ; Isabelle Pellegrin [France] ; Juliette Bitard [France] ; Linda Wittkop [France] ; Cécile Proust-Lima [France] ; Benoît Liquet [France, Australie] ; Jean-François Moreau [France] ; Fabrice Bonnet [France] ; Patrick Blanco [France] ; Rodolphe Thiébaut [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN ribosomique 16S (métabolisme), Activation des lymphocytes, Adulte, Adulte d'âge moyen, Algorithmes, Analyse multivariée, Antigènes CD38 (métabolisme), Antigènes HLA-DR (métabolisme), Antirétroviraux (usage thérapeutique), Auto-immunité (immunologie), Cytomegalovirus, Facteurs de risque, Femelle, France, Humains, Infections à VIH (), Infections à VIH (immunologie), Interféron alpha (immunologie), Lymphocytes T (immunologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Maladie chronique, Modèles statistiques, Mâle, Études de cohortes, Études transversales.
- MESH :
- immunologie : Auto-immunité, Infections à VIH, Interféron alpha, Lymphocytes T, Lymphocytes T CD4+, Lymphocytes T CD8+.
- métabolisme : ARN ribosomique 16S, Antigènes CD38, Antigènes HLA-DR.
- usage thérapeutique : Antirétroviraux.
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Algorithmes, Analyse multivariée, Cytomegalovirus, Facteurs de risque, Femelle, France, Humains, Infections à VIH, Maladie chronique, Modèles statistiques, Mâle, Études de cohortes, Études transversales.
English descriptors
- KwdEn :
- Adult, Algorithms, Anti-Retroviral Agents (therapeutic use), Antigens, CD38 (metabolism), Autoimmunity (immunology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, HIV Infections (immunology), HIV Infections (therapy), HLA-DR Antigens (metabolism), Humans, Interferon-alpha (immunology), Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, RNA, Ribosomal, 16S (metabolism), Risk Factors, T-Lymphocytes (immunology).
- MESH :
- chemical , immunology : Interferon-alpha.
- chemical , metabolism : Antigens, CD38, HLA-DR Antigens, RNA, Ribosomal, 16S.
- chemical , therapeutic use : Anti-Retroviral Agents.
- immunology : Autoimmunity, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, HIV Infections, T-Lymphocytes.
- therapy : HIV Infections.
- Adult, Algorithms, Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, Humans, Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, Risk Factors.
Abstract
To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.
Cross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.
Patients initiated antiretroviral therapy between 2005 and 2008 and were treated with sustained virological suppression for at least two years. CIA was defined by the percentage of HLA-DR+/CD38+ among CD8+T-cells. Integrative analyses were performed using structural equation modelling (SEM).
The main analysis was performed in 57 HLA-A*0201 positive patients, due to availability of percentages of actin-, vimentin-, lamin-specific CD8+T-cells (HLA-A2-restricted tests) to further characterize autoimmune response. Cytomegalovirus-induced response was assessed by Quantiferon and pp-65 ELISPOT. SEM revealed a direct effect of cytomegalovirus-induced response on CIA (standardized estimate βstd = 0.56, p-value = 0.0004). The effect of autoimmune-induced response on CIA was indirect through alpha-interferon pathway, assessed by expression levels of 5 alpha-interferon-stimulated genes ADAR, ISG15, IFIT1, Mx1 and OAS1 (effect of autoimmune response on alpha-interferon: βstd = 0.36, p-value = 0.0401; effect of alpha-interferon on CIA: βstd = 0.39, p-value = 0.0044). There was no direct effect of autoimmune-induced response on CIA (p-value = 0.3169). Microbial translocation as measured by 16SrDNA and sCD14 in plasma was not associated with CIA. Results were consistent in 142 patients in whom cytomegalovirus and auto-immunity responses were measured by Quantiferon and anti-nuclear antibodies, respectively. All analyses performed in HLA-A*0201 positive patients and in the overall population revealed a significant effect of IFN-α latent variable on CIA.
The role of cytomegalovirus-induced response on CIA was confirmed as well as the involvement of alpha-interferon on CIA. The indirect effect of auto-immunity response on CIA revealed through the alpha-interferon pathway requires further investigation to confirm the potential role of auto-immunity for CIA in HIV-infected patients.
Url:
DOI: 10.1371/journal.pone.0169164
PubMed: 28046052
PubMed Central: 5207686
Affiliations:
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Bordeaux, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>INRIA, Team SISTM, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA, Team SISTM, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28046052</idno><idno type="pmc">5207686</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207686</idno><idno type="RBID">PMC:5207686</idno><idno type="doi">10.1371/journal.pone.0169164</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002962</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002962</idno><idno type="wicri:Area/Pmc/Curation">002812</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002812</idno><idno type="wicri:Area/Pmc/Checkpoint">000238</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000238</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001236</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001236</idno><idno type="wicri:Area/PubMed/Curation">001225</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001225</idno><idno type="wicri:Area/PubMed/Checkpoint">001225</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001225</idno><idno type="wicri:Area/Ncbi/Merge">004116</idno><idno type="wicri:Area/Ncbi/Curation">004116</idno><idno type="wicri:Area/Ncbi/Checkpoint">004116</idno><idno type="wicri:Area/Main/Merge">000964</idno><idno type="wicri:Area/Main/Curation">000969</idno><idno type="wicri:Area/Main/Exploration">000969</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients</title><author><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Univ. Bordeaux, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>INRIA, Team SISTM, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA, Team SISTM, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Pellegrin, Isabelle" sort="Pellegrin, Isabelle" uniqKey="Pellegrin I" first="Isabelle" last="Pellegrin">Isabelle Pellegrin</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bitard, Juliette" sort="Bitard, Juliette" uniqKey="Bitard J" first="Juliette" last="Bitard">Juliette Bitard</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Univ. Bordeaux, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>INRIA, Team SISTM, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA, Team SISTM, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Univ. Bordeaux, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l’Adour, UMR CNRS 5142, Pau, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l’Adour, UMR CNRS 5142, Pau</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Pau</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>ARC Centre of Excellence for Mathematical and Statistical Frontiers, Queensland University of Technology (QUT), Brisbane, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence for Mathematical and Statistical Frontiers, Queensland University of Technology (QUT), Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Univ. Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>CNRS, UMR 5164, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 5164, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Univ. Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff011"><addr-line>Service de Médecine Interne et maladies Infectieuses, CHU de Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne et maladies Infectieuses, CHU de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Univ. Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>CNRS, UMR 5164, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 5164, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Univ. Bordeaux, ISPED, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>INRIA, Team SISTM, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRIA, Team SISTM, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Anti-Retroviral Agents (therapeutic use)</term><term>Antigens, CD38 (metabolism)</term><term>Autoimmunity (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Chronic Disease</term><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Cytomegalovirus</term><term>Female</term><term>France</term><term>HIV Infections (immunology)</term><term>HIV Infections (therapy)</term><term>HLA-DR Antigens (metabolism)</term><term>Humans</term><term>Interferon-alpha (immunology)</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Models, Statistical</term><term>Multivariate Analysis</term><term>RNA, Ribosomal, 16S (metabolism)</term><term>Risk Factors</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN ribosomique 16S (métabolisme)</term><term>Activation des lymphocytes</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Algorithmes</term><term>Analyse multivariée</term><term>Antigènes CD38 (métabolisme)</term><term>Antigènes HLA-DR (métabolisme)</term><term>Antirétroviraux (usage thérapeutique)</term><term>Auto-immunité (immunologie)</term><term>Cytomegalovirus</term><term>Facteurs de risque</term><term>Femelle</term><term>France</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (immunologie)</term><term>Interféron alpha (immunologie)</term><term>Lymphocytes T (immunologie)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Maladie chronique</term><term>Modèles statistiques</term><term>Mâle</term><term>Études de cohortes</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD38</term><term>HLA-DR Antigens</term><term>RNA, Ribosomal, 16S</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Auto-immunité</term><term>Infections à VIH</term><term>Interféron alpha</term><term>Lymphocytes T</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmunity</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>HIV Infections</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN ribosomique 16S</term><term>Antigènes CD38</term><term>Antigènes HLA-DR</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Chronic Disease</term><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Cytomegalovirus</term><term>Female</term><term>France</term><term>Humans</term><term>Lymphocyte Activation</term><term>Male</term><term>Middle Aged</term><term>Models, Statistical</term><term>Multivariate Analysis</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Algorithmes</term><term>Analyse multivariée</term><term>Cytomegalovirus</term><term>Facteurs de risque</term><term>Femelle</term><term>France</term><term>Humains</term><term>Infections à VIH</term><term>Maladie chronique</term><term>Modèles statistiques</term><term>Mâle</term><term>Études de cohortes</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title><p>To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</p></sec><sec id="sec002"><title>Design</title><p>Cross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.</p></sec><sec id="sec003"><title>Methods</title><p>Patients initiated antiretroviral therapy between 2005 and 2008 and were treated with sustained virological suppression for at least two years. CIA was defined by the percentage of HLA-DR+/CD38+ among CD8+T-cells. Integrative analyses were performed using structural equation modelling (SEM).</p></sec><sec id="sec004"><title>Results</title><p>The main analysis was performed in 57 HLA-A*0201 positive patients, due to availability of percentages of actin-, vimentin-, lamin-specific CD8+T-cells (HLA-A2-restricted tests) to further characterize autoimmune response. Cytomegalovirus-induced response was assessed by Quantiferon and pp-65 ELISPOT. SEM revealed a direct effect of cytomegalovirus-induced response on CIA (standardized estimate βstd = 0.56, p-value = 0.0004). The effect of autoimmune-induced response on CIA was indirect through alpha-interferon pathway, assessed by expression levels of 5 alpha-interferon-stimulated genes ADAR, ISG15, IFIT1, Mx1 and OAS1 (effect of autoimmune response on alpha-interferon: βstd = 0.36, p-value = 0.0401; effect of alpha-interferon on CIA: βstd = 0.39, p-value = 0.0044). There was no direct effect of autoimmune-induced response on CIA (p-value = 0.3169). Microbial translocation as measured by 16SrDNA and sCD14 in plasma was not associated with CIA. Results were consistent in 142 patients in whom cytomegalovirus and auto-immunity responses were measured by Quantiferon and anti-nuclear antibodies, respectively. All analyses performed in HLA-A*0201 positive patients and in the overall population revealed a significant effect of IFN-α latent variable on CIA.</p></sec><sec id="sec005"><title>Conclusion</title><p>The role of cytomegalovirus-induced response on CIA was confirmed as well as the involvement of alpha-interferon on CIA. The indirect effect of auto-immunity response on CIA revealed through the alpha-interferon pathway requires further investigation to confirm the potential role of auto-immunity for CIA in HIV-infected patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Kitchen, Cm" uniqKey="Kitchen C">CM Kitchen</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author><author><name sortKey="Gascon, R" uniqKey="Gascon R">R Gascon</name></author><author><name sortKey="Narvaez, Ab" uniqKey="Narvaez A">AB Narvaez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sodora, Dl" uniqKey="Sodora D">DL Sodora</name></author><author><name sortKey="Silvestri, G" uniqKey="Silvestri G">G Silvestri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsue, Py" uniqKey="Hsue P">PY Hsue</name></author><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Hunt, Pw" uniqKey="Hunt P">PW Hunt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plaeger, Sf" uniqKey="Plaeger S">SF Plaeger</name></author><author><name sortKey="Collins, Bs" uniqKey="Collins B">BS Collins</name></author><author><name sortKey="Musib, R" uniqKey="Musib R">R Musib</name></author><author><name sortKey="Deeks, Sg" uniqKey="Deeks S">SG Deeks</name></author><author><name sortKey="Read, S" uniqKey="Read S">S Read</name></author><author><name sortKey="Embry, A" uniqKey="Embry A">A Embry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tebas, P" uniqKey="Tebas P">P Tebas</name></author><author><name sortKey="Henry, Wk" uniqKey="Henry W">WK Henry</name></author><author><name sortKey="Matining, R" uniqKey="Matining R">R Matining</name></author><author><name sortKey="Weng Cherng, D" uniqKey="Weng Cherng D">D Weng-Cherng</name></author><author><name sortKey="Schmitz, J" uniqKey="Schmitz J">J Schmitz</name></author><author><name sortKey="Valdez, H" uniqKey="Valdez H">H Valdez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nasi, M" uniqKey="Nasi M">M Nasi</name></author><author><name sortKey="De Biasi, S" uniqKey="De Biasi S">S De Biasi</name></author><author><name sortKey="Gibellini, L" uniqKey="Gibellini L">L Gibellini</name></author><author><name sortKey="Bianchini, E" uniqKey="Bianchini E">E Bianchini</name></author><author><name sortKey="Pecorini, S" uniqKey="Pecorini S">S Pecorini</name></author><author><name sortKey="Bacca, V" uniqKey="Bacca V">V Bacca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name></author><author><name sortKey="Ng, C" uniqKey="Ng C">C Ng</name></author><author><name sortKey="Lee, Am" uniqKey="Lee A">AM Lee</name></author><author><name sortKey="Sullivan, Bm" uniqKey="Sullivan B">BM Sullivan</name></author><author><name sortKey="Sheehan, Kc" uniqKey="Sheehan K">KC Sheehan</name></author><author><name sortKey="Welch, M" uniqKey="Welch M">M Welch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Eb" uniqKey="Wilson E">EB Wilson</name></author><author><name sortKey="Yamada, Dh" uniqKey="Yamada D">DH Yamada</name></author><author><name sortKey="Elsaesser, H" uniqKey="Elsaesser H">H Elsaesser</name></author><author><name sortKey="Herskovitz, J" uniqKey="Herskovitz J">J Herskovitz</name></author><author><name sortKey="Deng, J" uniqKey="Deng J">J Deng</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Moorman, Jp" uniqKey="Moorman J">JP Moorman</name></author><author><name sortKey="Yao, Zq" uniqKey="Yao Z">ZQ Yao</name></author><author><name sortKey="Jia, Zs" uniqKey="Jia Z">ZS Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acchioni, C" uniqKey="Acchioni C">C Acchioni</name></author><author><name sortKey="Marsili, G" uniqKey="Marsili G">G Marsili</name></author><author><name sortKey="Perrotti, E" uniqKey="Perrotti E">E Perrotti</name></author><author><name sortKey="Remoli, Al" uniqKey="Remoli A">AL Remoli</name></author><author><name sortKey="Sgarbanti, M" uniqKey="Sgarbanti M">M Sgarbanti</name></author><author><name sortKey="Battistini, A" uniqKey="Battistini A">A Battistini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cha, L" uniqKey="Cha L">L Cha</name></author><author><name sortKey="Berry, Cm" uniqKey="Berry C">CM Berry</name></author><author><name sortKey="Nolan, D" uniqKey="Nolan D">D Nolan</name></author><author><name sortKey="Castley, A" uniqKey="Castley A">A Castley</name></author><author><name sortKey="Fernandez, S" uniqKey="Fernandez S">S Fernandez</name></author><author><name sortKey="French, Ma" uniqKey="French M">MA French</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ries, M" uniqKey="Ries M">M Ries</name></author><author><name sortKey="Pritschet, K" uniqKey="Pritschet K">K Pritschet</name></author><author><name sortKey="Schmidt, B" uniqKey="Schmidt B">B Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajasuriar, R" uniqKey="Rajasuriar R">R Rajasuriar</name></author><author><name sortKey="Khoury, G" uniqKey="Khoury G">G Khoury</name></author><author><name sortKey="Kamarulzaman, A" uniqKey="Kamarulzaman A">A Kamarulzaman</name></author><author><name sortKey="French, Ma" uniqKey="French M">MA French</name></author><author><name sortKey="Cameron, Pu" uniqKey="Cameron P">PU Cameron</name></author><author><name sortKey="Lewin, Sr" uniqKey="Lewin S">SR Lewin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Appay, V" uniqKey="Appay V">V Appay</name></author><author><name sortKey="Sauce, D" uniqKey="Sauce D">D Sauce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Price, Da" uniqKey="Price D">DA Price</name></author><author><name sortKey="Schacker, Tw" uniqKey="Schacker T">TW Schacker</name></author><author><name sortKey="Asher, Te" uniqKey="Asher T">TE Asher</name></author><author><name sortKey="Silvestri, G" uniqKey="Silvestri G">G Silvestri</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klatt, Nr" uniqKey="Klatt N">NR Klatt</name></author><author><name sortKey="Funderburg, Nt" uniqKey="Funderburg N">NT Funderburg</name></author><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Lederman, Mm" uniqKey="Lederman M">MM Lederman</name></author><author><name sortKey="Hunt, P" uniqKey="Hunt P">P Hunt</name></author><author><name sortKey="Sieg, Sf" uniqKey="Sieg S">SF Sieg</name></author><author><name sortKey="Haley, K" uniqKey="Haley K">K Haley</name></author><author><name sortKey="Rodriguez, B" uniqKey="Rodriguez B">B Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Appay, V" uniqKey="Appay V">V Appay</name></author><author><name sortKey="Fastenackels, S" uniqKey="Fastenackels S">S Fastenackels</name></author><author><name sortKey="Katlama, C" uniqKey="Katlama C">C Katlama</name></author><author><name sortKey="Ait Mohand, H" uniqKey="Ait Mohand H">H Ait-Mohand</name></author><author><name sortKey="Schneider, L" uniqKey="Schneider L">L Schneider</name></author><author><name sortKey="Guihot, A" uniqKey="Guihot A">A Guihot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsue, Py" uniqKey="Hsue P">PY Hsue</name></author><author><name sortKey="Hunt, Pw" uniqKey="Hunt P">PW Hunt</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Bredt, B" uniqKey="Bredt B">B Bredt</name></author><author><name sortKey="Franklin, A" uniqKey="Franklin A">A Franklin</name></author><author><name sortKey="Killian, M" uniqKey="Killian M">M Killian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parrinello, Cm" uniqKey="Parrinello C">CM Parrinello</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Landay, Al" uniqKey="Landay A">AL Landay</name></author><author><name sortKey="Lurain, N" uniqKey="Lurain N">N Lurain</name></author><author><name sortKey="Sharrett, Ar" uniqKey="Sharrett A">AR Sharrett</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunt, Pw" uniqKey="Hunt P">PW Hunt</name></author><author><name sortKey="Martin, Jn" uniqKey="Martin J">JN Martin</name></author><author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E Sinclair</name></author><author><name sortKey="Epling, L" uniqKey="Epling L">L Epling</name></author><author><name sortKey="Teague, J" uniqKey="Teague J">J Teague</name></author><author><name sortKey="Jacobson, Ma" uniqKey="Jacobson M">MA Jacobson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stratton, R" uniqKey="Stratton R">R Stratton</name></author><author><name sortKey="Slapak, G" uniqKey="Slapak G">G Slapak</name></author><author><name sortKey="Mahungu, T" uniqKey="Mahungu T">T Mahungu</name></author><author><name sortKey="Kinloch De Loes, S" uniqKey="Kinloch De Loes S">S Kinloch-de Loes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rawson, Pm" uniqKey="Rawson P">PM Rawson</name></author><author><name sortKey="Molette, C" uniqKey="Molette C">C Molette</name></author><author><name sortKey="Videtta, M" uniqKey="Videtta M">M Videtta</name></author><author><name sortKey="Altieri, L" uniqKey="Altieri L">L Altieri</name></author><author><name sortKey="Franceschini, D" uniqKey="Franceschini D">D Franceschini</name></author><author><name sortKey="Donato, T" uniqKey="Donato T">T Donato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wittkop, L" uniqKey="Wittkop L">L Wittkop</name></author><author><name sortKey="Bitard, J" uniqKey="Bitard J">J Bitard</name></author><author><name sortKey="Lazaro, E" uniqKey="Lazaro E">E Lazaro</name></author><author><name sortKey="Neau, D" uniqKey="Neau D">D Neau</name></author><author><name sortKey="Bonnet, F" uniqKey="Bonnet F">F Bonnet</name></author><author><name sortKey="Mercie, P" uniqKey="Mercie P">P Mercie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name></author><author><name sortKey="Pascual, V" uniqKey="Pascual V">V Pascual</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blanco, P" uniqKey="Blanco P">P Blanco</name></author><author><name sortKey="Palucka, Ak" uniqKey="Palucka A">AK Palucka</name></author><author><name sortKey="Pascual, V" uniqKey="Pascual V">V Pascual</name></author><author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinloch, Aj" uniqKey="Kinloch A">AJ Kinloch</name></author><author><name sortKey="Chang, A" uniqKey="Chang A">A Chang</name></author><author><name sortKey="Ko, K" uniqKey="Ko K">K Ko</name></author><author><name sortKey="Henry Dunand, Cj" uniqKey="Henry Dunand C">CJ Henry Dunand</name></author><author><name sortKey="Henderson, S" uniqKey="Henderson S">S Henderson</name></author><author><name sortKey="Maienschein Cline, M" uniqKey="Maienschein Cline M">M Maienschein-Cline</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Netterwald, J" uniqKey="Netterwald J">J Netterwald</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, Bn" uniqKey="Sanchez B">BN Sanchez</name></author><author><name sortKey="Budtz Jorgensen, E" uniqKey="Budtz Jorgensen E">E Budtz-Jorgensen</name></author><author><name sortKey="Ryan, Lm" uniqKey="Ryan L">LM Ryan</name></author><author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiebaut, R" uniqKey="Thiebaut R">R Thiebaut</name></author><author><name sortKey="Morlat, P" uniqKey="Morlat P">P Morlat</name></author><author><name sortKey="Jacqmin Gadda, H" uniqKey="Jacqmin Gadda H">H Jacqmin-Gadda</name></author><author><name sortKey="Neau, D" uniqKey="Neau D">D Neau</name></author><author><name sortKey="Mercie, P" uniqKey="Mercie P">P Mercie</name></author><author><name sortKey="Dabis, F" uniqKey="Dabis F">F Dabis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivashkiv, Lb" uniqKey="Ivashkiv L">LB Ivashkiv</name></author><author><name sortKey="Donlin, Lt" uniqKey="Donlin L">LT Donlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benito, Jm" uniqKey="Benito J">JM Benito</name></author><author><name sortKey="L Pez, M" uniqKey="L Pez M">M López</name></author><author><name sortKey="Lozano, S" uniqKey="Lozano S">S Lozano</name></author><author><name sortKey="Martinez, P" uniqKey="Martinez P">P Martinez</name></author><author><name sortKey="Gonzalez Lahoz, J" uniqKey="Gonzalez Lahoz J">J González-Lahoz</name></author><author><name sortKey="Soriano, V" uniqKey="Soriano V">V Soriano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blanco, P" uniqKey="Blanco P">P Blanco</name></author><author><name sortKey="Pitard, V" uniqKey="Pitard V">V Pitard</name></author><author><name sortKey="Viallard, Jf" uniqKey="Viallard J">JF Viallard</name></author><author><name sortKey="Taupin, Jl" uniqKey="Taupin J">JL Taupin</name></author><author><name sortKey="Pellegrin, Jl" uniqKey="Pellegrin J">JL Pellegrin</name></author><author><name sortKey="Moreau, Jf" uniqKey="Moreau J">JF Moreau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grace, J B" uniqKey="Grace J">J B Grace</name></author><author><name sortKey="Schoolmaster, Dr" uniqKey="Schoolmaster D">DR Schoolmaster</name></author><author><name sortKey="Guntenspergen, Gr" uniqKey="Guntenspergen G">GR Guntenspergen</name></author><author><name sortKey="Little, Am" uniqKey="Little A">AM Little</name></author><author><name sortKey="Mitchell, Br" uniqKey="Mitchell B">BR Mitchell</name></author><author><name sortKey="Miller, Km" uniqKey="Miller K">KM Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chavance, M" uniqKey="Chavance M">M Chavance</name></author><author><name sortKey="Escolano, S" uniqKey="Escolano S">S Escolano</name></author><author><name sortKey="Romon, M" uniqKey="Romon M">M Romon</name></author><author><name sortKey="Basdevant, A" uniqKey="Basdevant A">A Basdevant</name></author><author><name sortKey="De Lauzon Guillain, B" uniqKey="De Lauzon Guillain B">B de Lauzon-Guillain</name></author><author><name sortKey="Charles, Ma" uniqKey="Charles M">MA Charles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahly, Dl" uniqKey="Dahly D">DL Dahly</name></author><author><name sortKey="Adair, Ls" uniqKey="Adair L">LS Adair</name></author><author><name sortKey="Bollen, Ka" uniqKey="Bollen K">KA Bollen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holst, Kk" uniqKey="Holst K">KK Holst</name></author><author><name sortKey="J, E" uniqKey="J E">E J</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoyle, Rh" uniqKey="Hoyle R">RH Hoyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, Lt" uniqKey="Hu L">LT Hu</name></author><author><name sortKey="Bentler, Pm" uniqKey="Bentler P">PM Bentler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genser, B" uniqKey="Genser B">B Genser</name></author><author><name sortKey="Cooper, Pj" uniqKey="Cooper P">PJ Cooper</name></author><author><name sortKey="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M">M Yazdanbakhsh</name></author><author><name sortKey="Barreto, Ml" uniqKey="Barreto M">ML Barreto</name></author><author><name sortKey="Rodrigues, Lc" uniqKey="Rodrigues L">LC Rodrigues</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanf, M" uniqKey="Hanf M">M Hanf</name></author><author><name sortKey="Guegan, Jf" uniqKey="Guegan J">JF Guégan</name></author><author><name sortKey="Ahmed, I" uniqKey="Ahmed I">I Ahmed</name></author><author><name sortKey="Nacher, M" uniqKey="Nacher M">M Nacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Jr" uniqKey="Brown J">JR Brown</name></author><author><name sortKey="Stafford, P" uniqKey="Stafford P">P Stafford</name></author><author><name sortKey="Johnston, Sa" uniqKey="Johnston S">SA Johnston</name></author><author><name sortKey="Dinu, V" uniqKey="Dinu V">V Dinu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tetard Jones, C" uniqKey="Tetard Jones C">C Tétard-Jones</name></author><author><name sortKey="Gatehouse, Am" uniqKey="Gatehouse A">AM Gatehouse</name></author><author><name sortKey="Cooper, J" uniqKey="Cooper J">J Cooper</name></author><author><name sortKey="Leifert, C" uniqKey="Leifert C">C Leifert</name></author><author><name sortKey="Rushton, S" uniqKey="Rushton S">S Rushton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, Ml" uniqKey="Freeman M">ML Freeman</name></author><author><name sortKey="Lederman, Mm" uniqKey="Lederman M">MM Lederman</name></author><author><name sortKey="Gianella, S" uniqKey="Gianella S">S Gianella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gianella, S" uniqKey="Gianella S">S Gianella</name></author><author><name sortKey="Letendre, S" uniqKey="Letendre S">S Letendre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lichtner, M" uniqKey="Lichtner M">M Lichtner</name></author><author><name sortKey="Cicconi, P" uniqKey="Cicconi P">P Cicconi</name></author><author><name sortKey="Vita, S" uniqKey="Vita S">S Vita</name></author><author><name sortKey="Cozzi Lepri, A" uniqKey="Cozzi Lepri A">A Cozzi-Lepri</name></author><author><name sortKey="Galli, M" uniqKey="Galli M">M Galli</name></author><author><name sortKey="Lo Caputo, S" uniqKey="Lo Caputo S">S Lo Caputo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Effros, Rb" uniqKey="Effros R">RB Effros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, Ml" uniqKey="Freeman M">ML Freeman</name></author><author><name sortKey="Mudd, Jc" uniqKey="Mudd J">JC Mudd</name></author><author><name sortKey="Shive, Cl" uniqKey="Shive C">CL Shive</name></author><author><name sortKey="Younes, Sa" uniqKey="Younes S">SA Younes</name></author><author><name sortKey="Panigrahi, S" uniqKey="Panigrahi S">S Panigrahi</name></author><author><name sortKey="Sieg, Sf" uniqKey="Sieg S">SF Sieg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, Sf" uniqKey="Stone S">SF Stone</name></author><author><name sortKey="Price, P" uniqKey="Price P">P Price</name></author><author><name sortKey="Khan, N" uniqKey="Khan N">N Khan</name></author><author><name sortKey="Moss, Pa" uniqKey="Moss P">PA Moss</name></author><author><name sortKey="French, Ma" uniqKey="French M">MA French</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thom, Jt" uniqKey="Thom J">JT Thom</name></author><author><name sortKey="Oxenius, A" uniqKey="Oxenius A">A Oxenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abad Fernandez, M" uniqKey="Abad Fernandez M">M Abad-Fernandez</name></author><author><name sortKey="Vallejo, A" uniqKey="Vallejo A">A Vallejo</name></author><author><name sortKey="Hernandez Novoa, B" uniqKey="Hernandez Novoa B">B Hernandez-Novoa</name></author><author><name sortKey="Diaz, L" uniqKey="Diaz L">L Diaz</name></author><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C Gutierrez</name></author><author><name sortKey="Madrid, N" uniqKey="Madrid N">N Madrid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author><author><name sortKey="Takeda, K" uniqKey="Takeda K">K Takeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kader, M" uniqKey="Kader M">M Kader</name></author><author><name sortKey="Smith, Ap" uniqKey="Smith A">AP Smith</name></author><author><name sortKey="Guiducci, C" uniqKey="Guiducci C">C Guiducci</name></author><author><name sortKey="Wonderlich, Er" uniqKey="Wonderlich E">ER Wonderlich</name></author><author><name sortKey="Normolle, D" uniqKey="Normolle D">D Normolle</name></author><author><name sortKey="Watkins, Sc" uniqKey="Watkins S">SC Watkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meier, A" uniqKey="Meier A">A Meier</name></author><author><name sortKey="Alter, G" uniqKey="Alter G">G Alter</name></author><author><name sortKey="Frahm, N" uniqKey="Frahm N">N Frahm</name></author><author><name sortKey="Sidhu, H" uniqKey="Sidhu H">H Sidhu</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Bagchi, A" uniqKey="Bagchi A">A Bagchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunson, Db" uniqKey="Dunson D">DB Dunson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, Wm" uniqKey="Schneider W">WM Schneider</name></author><author><name sortKey="Chevillotte, Md" uniqKey="Chevillotte M">MD Chevillotte</name></author><author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoggins, Jw" uniqKey="Schoggins J">JW Schoggins</name></author><author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younas, M" uniqKey="Younas M">M Younas</name></author><author><name sortKey="Psomas, C" uniqKey="Psomas C">C Psomas</name></author><author><name sortKey="Reynes, J" uniqKey="Reynes J">J Reynes</name></author><author><name sortKey="Corbeau, P" uniqKey="Corbeau P">P Corbeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Cy" uniqKey="Huang C">CY Huang</name></author><author><name sortKey="Lu, Cw" uniqKey="Lu C">CW Lu</name></author><author><name sortKey="Liu, Yl" uniqKey="Liu Y">YL Liu</name></author><author><name sortKey="Chiang, Ch" uniqKey="Chiang C">CH Chiang</name></author><author><name sortKey="Lee, Lt" uniqKey="Lee L">LT Lee</name></author><author><name sortKey="Huang, Kc" uniqKey="Huang K">KC Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baltar, Vt" uniqKey="Baltar V">VT Baltar</name></author><author><name sortKey="Xun, Ww" uniqKey="Xun W">WW Xun</name></author><author><name sortKey="Johansson, M" uniqKey="Johansson M">M Johansson</name></author><author><name sortKey="Ferrari, P" uniqKey="Ferrari P">P Ferrari</name></author><author><name sortKey="Chuang, Sc" uniqKey="Chuang S">SC Chuang</name></author><author><name sortKey="Relton, C" uniqKey="Relton C">C Relton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimizu, H" uniqKey="Shimizu H">H Shimizu</name></author><author><name sortKey="Arimura, Y" uniqKey="Arimura Y">Y Arimura</name></author><author><name sortKey="Onodera, K" uniqKey="Onodera K">K Onodera</name></author><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name></author><author><name sortKey="Okahara, S" uniqKey="Okahara S">S Okahara</name></author><author><name sortKey="Kodaira, J" uniqKey="Kodaira J">J Kodaira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogensen, Ub" uniqKey="Mogensen U">UB Mogensen</name></author><author><name sortKey="Grandjean, P" uniqKey="Grandjean P">P Grandjean</name></author><author><name sortKey="Heilmann, C" uniqKey="Heilmann C">C Heilmann</name></author><author><name sortKey="Nielsen, F" uniqKey="Nielsen F">F Nielsen</name></author><author><name sortKey="Weihe, P" uniqKey="Weihe P">P Weihe</name></author><author><name sortKey="Budtz J Rgensen, E" uniqKey="Budtz J Rgensen E">E Budtz-Jørgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genser, B" uniqKey="Genser B">B Genser</name></author><author><name sortKey="Fischer, Je" uniqKey="Fischer J">JE Fischer</name></author><author><name sortKey="Figueiredo, Ca" uniqKey="Figueiredo C">CA Figueiredo</name></author><author><name sortKey="Alcantara Neves, N" uniqKey="Alcantara Neves N">N Alcântara-Neves</name></author><author><name sortKey="Barreto, Ml" uniqKey="Barreto M">ML Barreto</name></author><author><name sortKey="Cooper, Pj" uniqKey="Cooper P">PJ Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carver, S" uniqKey="Carver S">S Carver</name></author><author><name sortKey="Beatty, Ja" uniqKey="Beatty J">JA Beatty</name></author><author><name sortKey="Troyer, Rm" uniqKey="Troyer R">RM Troyer</name></author><author><name sortKey="Harris, Rl" uniqKey="Harris R">RL Harris</name></author><author><name sortKey="Stutzman Rodriguez, K" uniqKey="Stutzman Rodriguez K">K Stutzman-Rodriguez</name></author><author><name sortKey="Barrs, Vr" uniqKey="Barrs V">VR Barrs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paiardini, M" uniqKey="Paiardini M">M Paiardini</name></author><author><name sortKey="Muller Trutwin, M" uniqKey="Muller Trutwin M">M Müller-Trutwin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Créteil</li><li>Pau</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name></region><name sortKey="Bitard, Juliette" sort="Bitard, Juliette" uniqKey="Bitard J" first="Juliette" last="Bitard">Juliette Bitard</name><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name><name sortKey="Pellegrin, Isabelle" sort="Pellegrin, Isabelle" uniqKey="Pellegrin I" first="Isabelle" last="Pellegrin">Isabelle Pellegrin</name><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name></country><country name="Australie"><noRegion><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name></noRegion></country></tree></affiliations></record>Pour manipuler ce 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